Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease

Parkinson's disease (PD) involves progressive loss of nigrostriatal dopamine (DA) neurons over an extended period of time. Mitochondrial damage may lead to PD, and neurotoxins affecting mitochondria are widely used to produce degeneration of the nigrostriatal circuitry. Deletion of the mitochon...

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Detalhes bibliográficos
Main Authors: Good, Cameron H., Hoffman, Alexander F., Hoffer, Barry J., Chefer, Vladimir I., Shippenberg, Toni S., Bäckman, Cristina M., Larsson, Nils-Göran, Olson, Lars, Gellhaar, Sandra, Galter, Dagmar, Lupica, Carl R.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2011
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3058704/
https://ncbi.nlm.nih.gov/pubmed/21233488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-173625
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