The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release

The pathogenic bacterium Helicobacter pylori produces the cytotoxin VacA, which is implicated in the genesis of gastric epithelial lesions. By transfect ing HEp-2 cells with DNAs encoding either the N-terminal (p34) or the C-terminal (p58) fragment of VacA, p34 was found localized specifically to mi...

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Main Authors: Galmiche, Antoine, Rassow, Joachim, Doye, Anne, Cagnol, Sebastien, Chambard, Jean-Claude, Contamin, Stephanette, de Thillot, Virginie, Just, Ingo, Ricci, Vittorio, Solcia, Enrico, Van Obberghen, Ellen, Boquet, Patrice
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC305856/
https://ncbi.nlm.nih.gov/pubmed/11101509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.23.6361
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