The p21 Rho-activating Toxin Cytotoxic Necrotizing Factor 1 Is Endocytosed by a Clathrin-independent Mechanism and Enters the Cytosol by an Acidic-dependent Membrane Translocation Step

Cytotoxic necrotizing factor 1 (CNF1), a protein produced by pathogenic strains of Escherichia coli, activates the p21 Rho-GTP-binding protein, inducing a profound reorganization of the actin cytoskeleton. CNF1 binds to its cell surface receptor on HEp-2 cells with high affinity (K(d) = 20 pM). In H...

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Detalhes bibliográficos

Publicado no:	Mol Biol Cell
Principais autores:	Contamin, Stephanette, Galmiche, Antoine, Doye, Anne, Flatau, Gilles, Benmerah, Alexandre, Boquet, Patrice
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Cell Biology 2000
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC14883/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10793151/ https://ncbi.nlm.nih.govhttps://doi.org/10.1091/mbc.11.5.1775
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