Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells
GCN2 stimulates GCN4 translation in amino acid-starved cells by phosphorylating the α-subunit of translation initiation factor 2. GCN2 function in vivo requires the GCN1/GCN20 complex, which binds to the N-terminal domain of GCN2. A C-terminal segment of GCN1 (residues 2052–2428) was found to be nec...
Enregistré dans:
| Publié dans: | EMBO J |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group
2000
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305848/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11101534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.23.6622 |
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