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A Small-molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis
P53 inactivation caused by aberrant expression of its major regulators (e.g., MDM2 and MDMX) contributes to the genesis of a large number of human cancers. Recent studies have demonstrated that restoration of p53 activity by counteracting p53 repressors is a promising anti-cancer strategy. Although...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3058295/ https://ncbi.nlm.nih.gov/pubmed/21075910 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0581 |
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