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Activating Transcription Factor 3 Activates p53 by Preventing E6-associated Protein from Binding to E6
Genomic integration of human papillomavirus (HPV) DNA accounts for more than 90% of cervical cancers. High-risk genital HPVs encode E6 proteins that can interact with a cellular ubiquitin ligase E6-associated protein (E6AP) and target the tumor suppressor p53 for ubiquitin-mediated proteolysis. Curr...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2857083/ https://ncbi.nlm.nih.gov/pubmed/20167600 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.058669 |
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