Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription.

The transforming proteins of DNA tumor viruses SV40, adenovirus and human papillomaviruses (HPV) bind the retinoblastoma and p53 cell cycle regulatory proteins. While the binding of SV40 large T antigen and the adenovirus E1B 55 kDa protein results in the stabilization of the p53 protein, the bindin...

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Enregistré dans:
Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Lechner, M S, Mack, D H, Finicle, A B, Crook, T, Vousden, K H, Laimins, L A
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 1992
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556787/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1379175/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05375.x
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