Erythroid overexpression of C/EBPγ in transgenic mice affects γ-globin expression and fetal liver erythropoiesis

The CCAAT boxes of the β-like globin genes interact with three proteins: NF-Y, GATA-1 and NFE-6. We demonstrate that NFE-6 contains C/EBPγ, and address its role in globin gene regulation by erythroid overexpression of C/EBPγ, and a dominant-negative form C/EBPγΔB, in mice. Elevated levels of C/EBPγ,...

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Veröffentlicht in:	EMBO J
Hauptverfasser:	Zafarana, Gaetano, Rottier, Robbert, Grosveld, Frank, Philipsen, Sjaak
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2000
Schlagworte:	Articles
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305797/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11060036/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.21.5856
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