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Rotational Position of a 5-Methylcytosine-containing Cyclobutane Pyrimidine Dimer in a Nucleosome Greatly Affects Its Deamination Rate

C to T mutation hotspots in skin cancers occur primarily at methylated CpG sites that coincide with sites of UV-induced cyclobutane pyrimidine dimer (CPD) formation. These mutations are proposed to arise from the insertion of A by DNA polymerase η opposite the T that results from deamination of the...

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Detalhes bibliográficos
Main Authors: Song, Qian, Cannistraro, Vincent J., Taylor, John-Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057863/
https://ncbi.nlm.nih.gov/pubmed/21160086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.183178
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