Crystal structure of the human α-thrombin–haemadin complex: an exosite II-binding inhibitor

The serine proteinase α-thrombin plays a pivotal role in the regulation of blood fluidity, and therefore constitutes a primary target in the treatment of various haemostatic disorders. Haemadin is a slow tight- binding thrombin inhibitor from the land-living leech Haemadipsa sylvestris. Here we pres...

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書誌詳細

出版年:	EMBO J
主要な著者:	Richardson, John L., Kröger, Burkhard, Hoeffken, Wolfgang, Sadler, J.Evan, Pereira, Pedro, Huber, Robert, Bode, Wolfram, Fuentes-Prior, Pablo
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Publishing Group 2000
主題:	Articles
オンライン･アクセス:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11060016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.21.5650
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