Crystal structure of the human α-thrombin–haemadin complex: an exosite II-binding inhibitor

The serine proteinase α-thrombin plays a pivotal role in the regulation of blood fluidity, and therefore constitutes a primary target in the treatment of various haemostatic disorders. Haemadin is a slow tight- binding thrombin inhibitor from the land-living leech Haemadipsa sylvestris. Here we pres...

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Bibliographic Details
Main Authors: Richardson, John L., Kröger, Burkhard, Hoeffken, Wolfgang, Sadler, J.Evan, Pereira, Pedro, Huber, Robert, Bode, Wolfram, Fuentes-Prior, Pablo
Format: Artigo
Language:Inglês
Published: Oxford University Press 2000
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC305786/
https://ncbi.nlm.nih.gov/pubmed/11060016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.21.5650
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