Crystal structure of the human α-thrombin–haemadin complex: an exosite II-binding inhibitor
The serine proteinase α-thrombin plays a pivotal role in the regulation of blood fluidity, and therefore constitutes a primary target in the treatment of various haemostatic disorders. Haemadin is a slow tight- binding thrombin inhibitor from the land-living leech Haemadipsa sylvestris. Here we pres...
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| Publicado no: | EMBO J |
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| Principais autores: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11060016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.21.5650 |
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