Crystal structure of the human α-thrombin–haemadin complex: an exosite II-binding inhibitor

The serine proteinase α-thrombin plays a pivotal role in the regulation of blood fluidity, and therefore constitutes a primary target in the treatment of various haemostatic disorders. Haemadin is a slow tight- binding thrombin inhibitor from the land-living leech Haemadipsa sylvestris. Here we pres...

Fuld beskrivelse

Bibliografiske detaljer

Udgivet i:	EMBO J
Principais autores:	Richardson, John L., Kröger, Burkhard, Hoeffken, Wolfgang, Sadler, J.Evan, Pereira, Pedro, Huber, Robert, Bode, Wolfram, Fuentes-Prior, Pablo
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Publishing Group 2000
Fag:	Articles
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305786/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11060016/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/19.21.5650
Tags:	Tilføj Tag Ingen Tags, Vær først til at tagge denne postø!