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Protein Kinase Cβ2 inhibition reduces hyperglycemia-induced neural tube defects through suppression of a caspase8-triggered apoptotic pathway

BACKGROUND: Neural tube defects (NTDs) in infants of diabetic mothers are associated with increased protein kinase C β2 (PKCβ2) activity and programmed cell death (apoptosis) in the neuroepithelium during early embryogenesis. Apoptosis in diabetic embryopathy is triggered by caspase8, an initiator c...

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Detaylı Bibliyografya
Asıl Yazarlar: Cao, Yuanning, Zhao, Zhiyong, Eckert, Richard L., Reece, E. Albert
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057385/
https://ncbi.nlm.nih.gov/pubmed/21376163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajog.2011.01.013
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