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4-1BB Enhances Proliferation of Beryllium-Specific T Cells in the Lung of Subjects with Chronic Beryllium Disease

In contrast to naive T cells, reactivation of memory cells is less dependent on CD28-mediated costimulation. We have shown that circulating beryllium-specific CD4(+) T cells from chronic beryllium disease patients remain CD28-dependent, while those present in the lung no longer require CD28 for T ce...

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Main Authors: Mack, Douglas G., Lanham, Allison K., Palmer, Brent E., Maier, Lisa A., Watts, Tania H., Fontenot, Andrew P.
Format: Artigo
Jezik:Inglês
Izdano: 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057106/
https://ncbi.nlm.nih.gov/pubmed/18768897
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