PARP INHIBITION OR GENE DEFICIENCY COUNTERACT INTRAEPIDERMAL NERVE FIBER LOSS AND NEUROPATHIC PAIN IN ADVANCED DIABETIC NEUROPATHY

Evidence for important role of poly(ADP-ribose) polymerase (PARP) activation in diabetic complications is emerging. This study evaluated the role for PARP in rat and mouse models of advanced diabetic neuropathy. The orally active PARP inhibitor 10-(4-methyl-piperazin-1-ylmethyl)-2H-7-oxa-1,2-diaza-b...

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Bibliografiske detaljer
Main Authors: Obrosova, Irina G., Xu, Weizheng, Lyzogubov, Valeriy V., Ilnytska, Olga, Mashtalir, Nazar, Vareniuk, Igor, Pavlov, Ivan A., Zhang, Jie, Slusher, Barbara, Drel, Viktor R.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3057075/
https://ncbi.nlm.nih.gov/pubmed/17976390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2007.09.013
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