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Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1)
Human steroid 5β-reductase (Aldo-keto Reductase 1D1) catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of Δ(4)-ketosteroids to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. T...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056882/ https://ncbi.nlm.nih.gov/pubmed/21255593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.steroids.2011.01.003 |
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