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Structure and catalytic mechanism of human steroid 5β-reductase (AKR1D1)
Human steroid 5β-reductase (aldo-keto reductase (AKR) 1D1) catalyzes reduction of Δ(4)-ene double bonds in steroid hormones and bile acid precursors. We have reported the structures of an AKR1D1-NADP(+) binary complex, and AKR1D1-NADP(+)-cortisone, AKR1D1-NADP(+)-progesterone and AKR1D1-NADP(+)-test...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2675190/ https://ncbi.nlm.nih.gov/pubmed/18848863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2008.09.013 |
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