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Crystal Structure of Human Liver Δ(4)-3-Ketosteroid 5β-Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis
AKR1D1 (steroid 5β-reductase) reduces all Δ(4)-3-ketosteroids to form 5β-dihydrosteroids, a first step in the clearance of steroid hormones and an essential step in the synthesis of all bile acids. The reduction of the carbon-carbon double bond in an α,β-unsaturated ketone by 5β-reductase is a uniqu...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2423251/ https://ncbi.nlm.nih.gov/pubmed/18407998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M801778200 |
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