IL-21 and IL-6 Are Critical for Different Aspects of B Cell Immunity and Redundantly Induce Optimal Follicular Helper CD4 T Cell (Tfh) Differentiation

Cytokines are important modulators of lymphocytes, and both interleukin-21 (IL-21) and IL-6 have proposed roles in T follicular helper (Tfh) differentiation, and directly act on B cells. Here we investigated the absence of IL-6 alone, IL-21 alone, or the combined lack of IL-6 and IL-21 on Tfh differ...

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Detalhes bibliográficos
Main Authors: Eto, Danelle, Lao, Christopher, DiToro, Daniel, Barnett, Burton, Escobar, Tania C., Kageyama, Robin, Yusuf, Isharat, Crotty, Shane
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056724/
https://ncbi.nlm.nih.gov/pubmed/21423809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0017739
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