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Trp53 regulates Notch 4 signaling through Mdm2
Notch receptors and their ligands have crucial roles in development and tumorigenesis. We present evidence demonstrating the existence of an antagonistic relationship between Notch 4 and Trp53, which is controlled by the Mdm2-dependent ubiquitylation and degradation of the Notch receptor. We show th...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Company of Biologists
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056605/ https://ncbi.nlm.nih.gov/pubmed/21402876 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.068965 |
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