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In Vivo Analysis of the Notch Receptor S1 Cleavage

A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface. The in vivo consequences and significance of this cleavage on Drosophila Notch signaling remain unclear an...

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Autori principali: Lake, Robert J., Grimm, Lisa M., Veraksa, Alexey, Banos, Andrew, Artavanis-Tsakonas, Spyros
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2726433/
https://ncbi.nlm.nih.gov/pubmed/19701455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006728
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