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Blocking the NOTCH Pathway Inhibits Vascular Inflammation in Large Vessel Vasculitis

BACKGROUND: Giant cell arteritis (GCA) is a granulomatous vasculitis of the aorta and its branches that causes blindness, stroke and aortic aneurysm. CD4 T-cells are key pathogenic regulators, instructed by vessel wall dendritic cells (DC) to differentiate into vasculitic T cells. The unique pathway...

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Detaylı Bibliyografya
Asıl Yazarlar: Piggott, Kisha, Deng, Jiusheng, Warrington, Kenneth, Younge, Brian, Kubo, Jessica T., Desai, Manisha, Goronzy, Jörg J., Weyand, Cornelia M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056570/
https://ncbi.nlm.nih.gov/pubmed/21220737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.936203
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