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Dose-Levels and First Signs of Efficacy in Contemporary Oncology Phase 1 Clinical Trials
PURPOSE: Phase 1 trials play a crucial role in oncology by translating laboratory science into efficient therapies. Molecular targeted agents (MTA) differ from traditional cytotoxics in terms of both efficacy and toxicity profiles. Recent reports suggest that higher doses are not essential to produc...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3056556/ https://ncbi.nlm.nih.gov/pubmed/21415927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016633 |
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