Radiosynthesis and in vivo evaluation of [(11)C]MP-10 as a PET probe for imaging PDE10A in rodent and nonhuman primate brain

2-((4-(1-[(11)C]methyl-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-quinoline (MP-10), a specific PDE10A inhibitor (IC(50) = 0.18 nM with 100-fold selectivity over other PDEs), was radiosynthesized by alkylation of the desmethyl precursor with [(11)C]CH(3)I, ~45% yield, > 92% radiochemical pu...

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Autors principals: Tu, Zhude, Fan, Jinda, Li, Shihong, Jones, Lynne A., Cui, Jinquan, Padakanti, Prashanth K., Xu, Jinbin, Zeng, Dexing, Shoghi, Kooresh I., Perlmutter, Joel S., Mach, Robert H.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056285/
https://ncbi.nlm.nih.gov/pubmed/21315609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.01.032
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