Radiosynthesis and biological evaluation of a promising σ(2)-receptor ligand radiolabeled with fluorine-18 or iodine-125 as a PET/SPECT probe for imaging breast cancer

Sigma-2 receptors represent an endogenous marker for proliferation in solid tumors. The high affinity, high selectivity σ(2) receptor ligand N-(4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)butyl)-2-(2-fluoroethoxy)-5-iodo-3-methoxybenzamide (3) was separately radiolabeled with F-18 and I-125. Th...

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Bibliografiske detaljer
Main Authors: Tu, Zhude, Xu, Jinbin, Jones, Lynne A., Li, Shihong, Zeng, Dexing, Kung, Mei-Ping, Kung, Hank F., Mach, Robert H.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937058/
https://ncbi.nlm.nih.gov/pubmed/20594864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apradiso.2010.06.004
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