Decreased Neprilysin and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease

Rationale: Studies with genetically engineered mice showed that decreased expression of the transmembrane peptidase neprilysin (NEP) increases susceptibility to hypoxic pulmonary vascular remodeling and hypertension; in hypoxic wild-type mice, expression is decreased early in distal pulmonary arteri...

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Bibliographic Details
Main Authors: Wick, Marilee J., Buesing, Erica J., Wehling, Carol A., Loomis, Zoe L., Cool, Carlyne D., Zamora, Martin R., Miller, York E., Colgan, Sean P., Hersh, Louis B., Voelkel, Norbert F., Dempsey, Edward C.
Format: Artigo
Language:Inglês
Published: American Thoracic Society 2011
Subjects:
B. Chronic Obstructive Pulmonary Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056229/
https://ncbi.nlm.nih.gov/pubmed/20813891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201002-0154OC
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