Decreased Neprilysin and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease

Rationale: Studies with genetically engineered mice showed that decreased expression of the transmembrane peptidase neprilysin (NEP) increases susceptibility to hypoxic pulmonary vascular remodeling and hypertension; in hypoxic wild-type mice, expression is decreased early in distal pulmonary arteri...

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Detalhes bibliográficos
Main Authors: Wick, Marilee J., Buesing, Erica J., Wehling, Carol A., Loomis, Zoe L., Cool, Carlyne D., Zamora, Martin R., Miller, York E., Colgan, Sean P., Hersh, Louis B., Voelkel, Norbert F., Dempsey, Edward C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2011
Assuntos:
B. Chronic Obstructive Pulmonary Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056229/
https://ncbi.nlm.nih.gov/pubmed/20813891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201002-0154OC
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