Decreased Neprilysin and Pulmonary Vascular Remodeling in Chronic Obstructive Pulmonary Disease

Rationale: Studies with genetically engineered mice showed that decreased expression of the transmembrane peptidase neprilysin (NEP) increases susceptibility to hypoxic pulmonary vascular remodeling and hypertension; in hypoxic wild-type mice, expression is decreased early in distal pulmonary arteri...

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Autori principali: Wick, Marilee J., Buesing, Erica J., Wehling, Carol A., Loomis, Zoe L., Cool, Carlyne D., Zamora, Martin R., Miller, York E., Colgan, Sean P., Hersh, Louis B., Voelkel, Norbert F., Dempsey, Edward C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2011
Soggetti:
B. Chronic Obstructive Pulmonary Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056229/
https://ncbi.nlm.nih.gov/pubmed/20813891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201002-0154OC
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