Sustained Activation of RhoGTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice

OBJECTIVE: Pulmonary artery smooth muscle cells (PASMCs) from Neprilysin (NEP) null mice exhibit a synthetic phenotype and increased activation of RhoGTPases compared to their wild type (wt) counterparts. Although RhoGTPases are known to promote a contractile SMC phenotype, we hypothesize that their...

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Pubblicato in:Arterioscler Thromb Vasc Biol
Autori principali: Karoor, Vijaya, Fini, Mehdi A., Loomis, Zoe, Sullivan, Timothy, Hersh, Louis B., Gerasimovskaya, Evgenia, Irwin, David, Dempsey, Edward C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746466/
https://ncbi.nlm.nih.gov/pubmed/29191928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.310207
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