Neprilysin Null Mice Develop Exaggerated Pulmonary Vascular Remodeling in Response to Chronic Hypoxia

Neprilysin is a transmembrane metalloendopeptidase that degrades neuropeptides that are important for both growth and contraction. In addition to promoting carcinogenesis, decreased levels of neprilysin increases inflammation and neuroendocrine cell hyperplasia, which may predispose to vascular remo...

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Detalhes bibliográficos
Main Authors: Dempsey, Edward C., Wick, Marilee J., Karoor, Vijaya, Barr, Erica J., Tallman, Dustin W., Wehling, Carol A., Walchak, Sandra J., Laudi, Sven, Le, Mysan, Oka, Masahiko, Majka, Susan, Cool, Carlyne D., Fagan, Karen A., Klemm, Dwight J., Hersh, Louis B., Gerard, Norma P., Gerard, Craig, Miller, York E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2009
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665740/
https://ncbi.nlm.nih.gov/pubmed/19234135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.080345
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