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Triazolyl tryptoline derivatives as β-secretase inhibitors
Tryptoline, a core structure of ochrolifuanine E, which is a hit compound from virtual screening of the Thai herbal database against BACE1 was used as a scaffold for the design of BACE1 inhibitors. The tryptoline was linked with different side chains by 1,2,3-triazole ring readily synthesized by cat...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2010
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3055559/ https://ncbi.nlm.nih.gov/pubmed/20943389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2010.09.043 |
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