Age-Related Pseudocapillarization of the Liver Sinusoidal Endothelium Impairs the Hepatic Clearance of Acetaminophen in Rats

We investigated the effect of age-related pseudocapillarization of the liver sinusoidal endothelium on the hepatic disposition of acetaminophen. The multiple indicator dilution technique assessed the hepatic disposition of tracer (14)C-acetaminophen and reference markers in isolated perfused livers...

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Main Authors: Mitchell, Sarah J., Huizer-Pajkos, Aniko, Cogger, Victoria C., McLachlan, Andrew J., Le Couteur, David G., Jones, Brett, de Cabo, Rafael, Hilmer, Sarah N.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2011
Teme:
Journal of Gerontology: BIOLOGICAL SCIENCES
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055277/
https://ncbi.nlm.nih.gov/pubmed/21300741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glq221
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