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Excess histone levels mediate cytotoxicity via multiple mechanisms
The accumulation of excess histone proteins in cells has deleterious consequences such as genomic instability in the form of excessive chromosome loss, enhanced sensitivity to DNA damaging agents and cytotoxicity. Hence, the synthesis of histone proteins is tightly regulated at multiple steps and tr...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Landes Bioscience
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3055206/ https://ncbi.nlm.nih.gov/pubmed/20948314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.9.20.13636 |
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