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RNA methylation by Radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift
RlmN and Cfr are Radical SAM enzymes that modify a single adenosine nucleotide—A2503—in 23S ribosomal RNA. This nucleotide is positioned within the peptidyl transferase center of the ribosome, which is a target of numerous antibiotics. An unusual feature of these enzymes is their ability to carry ou...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3054002/ https://ncbi.nlm.nih.gov/pubmed/21368151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1017781108 |
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