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Covalent Intermediate in the Catalytic Mechanism of the Radical SAM Methyl Synthase RlmN Trapped by Mutagenesis

The posttranscriptional modification of ribosomal RNA (rRNA) modulates ribosomal function and confers resistance to antibiotics targeted to the ribosome. The radical SAM (S-adenosyl-L-methionine) methyl synthases, RlmN and Cfr, both methylate A2503 within the peptidyl transferase center (PTC) of pro...

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Detalhes bibliográficos
Main Authors: McCusker, Kevin P., Medzihradszky, Katalin F., Shiver, Anthony L., Nichols, Robert J., Yan, Feng, Maltby, David A., Gross, Carol A., Fujimori, Danica Galonić
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499099/
https://ncbi.nlm.nih.gov/pubmed/23088750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307855d
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