Covalent Intermediate in the Catalytic Mechanism of the Radical SAM Methyl Synthase RlmN Trapped by Mutagenesis

The posttranscriptional modification of ribosomal RNA (rRNA) modulates ribosomal function and confers resistance to antibiotics targeted to the ribosome. The radical SAM (S-adenosyl-L-methionine) methyl synthases, RlmN and Cfr, both methylate A2503 within the peptidyl transferase center (PTC) of pro...

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Bibliografische gegevens
Hoofdauteurs: McCusker, Kevin P., Medzihradszky, Katalin F., Shiver, Anthony L., Nichols, Robert J., Yan, Feng, Maltby, David A., Gross, Carol A., Fujimori, Danica Galonić
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2012
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3499099/
https://ncbi.nlm.nih.gov/pubmed/23088750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307855d
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