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Covalent Intermediate in the Catalytic Mechanism of the Radical SAM Methyl Synthase RlmN Trapped by Mutagenesis
The posttranscriptional modification of ribosomal RNA (rRNA) modulates ribosomal function and confers resistance to antibiotics targeted to the ribosome. The radical SAM (S-adenosyl-L-methionine) methyl synthases, RlmN and Cfr, both methylate A2503 within the peptidyl transferase center (PTC) of pro...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3499099/ https://ncbi.nlm.nih.gov/pubmed/23088750 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja307855d |
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