Effect of LKB1 deficiency on mitochondrial content, fiber type, and muscle performance in the mouse diaphragm

AIM: The Liver Kinase B1 (LKB1)/AMP-Activated Protein Kinase (AMPK) signaling pathway is a major regulator of skeletal muscle metabolic processes. During exercise, LKB1-mediated phosphorylation of AMPK leads to its activation, promoting mitochondrial biogenesis and glucose transport, among other eff...

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Главные авторы: Brown, Jacob D., Hancock, Chad R., Mongillo, Anthony D., Barton, J. Benjamin, DiGiovanni, Ryan A., Parcell, Allen C., Winder, William W., Thomson, David M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053411/
https://ncbi.nlm.nih.gov/pubmed/21073663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1748-1716.2010.02226.x
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