Gene Therapy Rescues Cone Structure and Function in the 3-Month-Old rd12 Mouse: A Model for Midcourse RPE65 Leber Congenital Amaurosis

PURPOSE. RPE65 function is necessary in the retinal pigment epithelium (RPE) to generate chromophore for all opsins. Its absence results in vision loss and rapid cone degeneration. Recent Leber congenital amaurosis type 2 (LCA with RPE65 mutations) phase I clinical trials demonstrated restoration of...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Li, Xia, Li, Wensheng, Dai, Xufeng, Kong, Fansheng, Zheng, Qinxiang, Zhou, Xiangtian, Lü, Fan, Chang, Bo, Rohrer, Bärbel, Hauswirth, William. W., Qu, Jia, Pang, Ji-jing
Materialtyp: Artigo
Språk:Inglês
Publicerad: Association for Research in Vision and Ophthalmology, Inc. 2011
Ämnen:
Articles
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053305/
https://ncbi.nlm.nih.gov/pubmed/21169527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.10-6138
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk