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Rpe65(−/−) and Lrat(−/−) Mice: Comparable Models of Leber Congenital Amaurosis
PURPOSE: The Rpe65(−/−) mouse, used as a model for Leber congenital amaurosis, has slow rod degeneration and rapid cone loss, presumably due to the mistrafficking of cone opsins. This animal does not generate 11-cis retinal and both the loss of cones and the rod response are restored by 11-cis retin...
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| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2641010/ https://ncbi.nlm.nih.gov/pubmed/18296659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.08-1727 |
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