Involvement of promoter methylation in the regulation of Pregnane X receptor in colon cancer cells

BACKGROUND: Pregnane X receptor (PXR) is a key transcription factor that regulates drug metabolizing enzymes such as cytochrome P450 (CYP) 3A4, and plays important roles in intestinal first-pass metabolism. Although there is a large inter-individual heterogeneity with intestinal CYP3A4 expression an...

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Detalhes bibliográficos
Main Authors: Habano, Wataru, Gamo, Toshie, Terashima, Jun, Sugai, Tamotsu, Otsuka, Koki, Wakabayashi, Go, Ozawa, Shogo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053268/
https://ncbi.nlm.nih.gov/pubmed/21342487
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-11-81
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