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Analysis of DNA methylation landscape reveals the roles of DNA methylation in the regulation of drug metabolizing enzymes

BACKGROUND: Drug metabolizing enzymes (DMEs) exhibit dramatic inter- and intra-individual variability in expression and activity. However, the mechanisms determining this variability have not been fully elucidated. The aim of this study was to evaluate the biological significance of DNA methylation...

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Detalhes bibliográficos
Publicado no:Clin Epigenetics
Main Authors: Habano, Wataru, Kawamura, Kohei, Iizuka, Natsuki, Terashima, Jun, Sugai, Tamotsu, Ozawa, Shogo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587720/
https://ncbi.nlm.nih.gov/pubmed/26421064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0136-7
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