Pregnane X-receptor promotes stem cell-mediated colon cancer relapse

Colorectal cancer lethality usually results from post-treatment relapse in the majority of stage II-IV patients, due to the enhanced resistance of Cancer Stem Cells (CSCs). Here, we show that the nuclear receptor Pregnane X Receptor (PXR, NR1I2), behaves as a key driver of CSC-mediated tumor recurre...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Planque, Chris, Rajabi, Fatemeh, Grillet, Fanny, Finetti, Pascal, Bertucci, François, Gironella, Meritxell, Lozano, Juan José, Beucher, Bertrand, Giraud, Julie, Garambois, Véronique, Vincent, Charles, Brown, Daniel, Caillo, Ludovic, Kantar, Jovana, Pelegrin, André, Prudhomme, Michel, Ripoche, Jérémie, Bourgaux, Jean François, Ginestier, Christophe, Castells, Antoni, Hollande, Frédéric, Pannequin, Julie, Pascussi, Jean Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5302934/
https://ncbi.nlm.nih.gov/pubmed/27448961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10646
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