Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation

BACKGROUND: Clinical efficacy of chemotherapy in colorectal cancer is subjected to broad inter-individual variations leading to the inability to predict outcome and toxicity. The topoisomerase I inhibitor irinotecan (CPT-11) is worldwide approved for the treatment of metastatic colorectal cancer and...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Raynal, Caroline, Pascussi, Jean-Marc, Leguelinel, Géraldine, Breuker, Cyril, Kantar, Jovana, Lallemant, Benjamin, Poujol, Sylvain, Bonnans, Caroline, Joubert, Dominique, Hollande, Frédéric, Lumbroso, Serge, Brouillet, Jean-Paul, Evrard, Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838814/
https://ncbi.nlm.nih.gov/pubmed/20196838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-9-46
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados