Regulation of Th1/Th17 cytokines and IDO gene expression by inhibition of calpain in PBMCs from MS patients

Multiple Sclerosis (MS) pathology is marked by the massive infiltration of myelin-specific T cells into the central nervous system (CNS). During active disease, pro-inflammatory Th1/Th17 cells predominate over immunoregulatory Th2/Treg cells. Here, we show that calpain inhibition downregulates Th1/T...

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Main Authors: Smith, Amena W., Doonan, Bently P., Tyor, William R., Abou-Fayssal, Nada, Haque, Azizul, Banik, Naren L.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3053080/
https://ncbi.nlm.nih.gov/pubmed/21075457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jneuroim.2010.09.030
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