Altered effector CD4(+) T cell function in IL-21R(−/−) CD4(+) T cell-mediated graft-versus-host disease

We previously showed that transplantation with interleukin-21 receptor (IL-21R) gene-deficient splenocytes resulted in less severe GVHD than was observed with wild type splenocytes. We now here sought to find mechanism(s) explaining this observation. Recipients of donor CD4(+) T cells lacking IL-21R...

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Hauptverfasser: Oh, Iekuni, Ozaki, Katsutoshi, Meguro, Akiko, Hatanaka, Keiko, Kadowaki, Masanori, Matsu, Haruko, Tatara, Raine, Sato, Kazuya, Iwakura, Yoichiro, Nakae, Susumu, Sudo, Katsuko, Teshima, Takanori, Leonard, Warren J., Ozawa, Keiya
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052859/
https://ncbi.nlm.nih.gov/pubmed/20574002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902217
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