Inositol pyrophosphates inhibit Akt signaling, regulate insulin sensitivity and weight gain

The inositol pyrophosphate IP7 (5-diphosphoinositolpentakisphosphate), formed by a family of three inositol hexakisphosphate kinases (IP6Ks), modulates diverse cellular activities. We now report that IP7 is a physiologic inhibitor of Akt, a serine/threonine kinase which regulates glucose homeostasis...

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Hlavní autoři: Chakraborty, Anutosh, Koldobskiy, Michael A., Bello, Nicholas T., Maxwell, Micah, Potter, James J., Juluri, Krishna R., Maag, David, Kim, Seyun, Huang, Alex S., Dailey, Megan J., Saleh, Masoumeh, Snowman, Adele M., Moran, Timothy H., Mezey, Esteban, Snyder, Solomon H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052691/
https://ncbi.nlm.nih.gov/pubmed/21145457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2010.11.032
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