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SCF(β-TRCP) links Chk1 signaling to degradation of the Cdc25A protein phosphatase
Eukaryotic cells respond to DNA damage and stalled replication forks by activating protein kinase-mediated signaling pathways that promote cell cycle arrest and DNA repair. A central target of the cell cycle arrest program is the Cdc25A protein phosphatase. Cdc25A is required for S-phase entry and d...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Cold Spring Harbor Laboratory Press
2003
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305258/ https://ncbi.nlm.nih.gov/pubmed/14681206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1157503 |
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