SCF(β-TRCP) links Chk1 signaling to degradation of the Cdc25A protein phosphatase

Eukaryotic cells respond to DNA damage and stalled replication forks by activating protein kinase-mediated signaling pathways that promote cell cycle arrest and DNA repair. A central target of the cell cycle arrest program is the Cdc25A protein phosphatase. Cdc25A is required for S-phase entry and d...

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Detalles Bibliográficos
Main Authors: Jin, Jianping, Shirogane, Takahiro, Xu, Lai, Nalepa, Grzegorz, Qin, Jun, Elledge, Stephen J., Harper, J. Wade
Formato: Artigo
Idioma:Inglês
Publicado: Cold Spring Harbor Laboratory Press 2003
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC305258/
https://ncbi.nlm.nih.gov/pubmed/14681206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1157503
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