SCF(β-TRCP) links Chk1 signaling to degradation of the Cdc25A protein phosphatase

Eukaryotic cells respond to DNA damage and stalled replication forks by activating protein kinase-mediated signaling pathways that promote cell cycle arrest and DNA repair. A central target of the cell cycle arrest program is the Cdc25A protein phosphatase. Cdc25A is required for S-phase entry and d...

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Detalhes bibliográficos

Publicado no:	Genes Dev
Principais autores:	Jin, Jianping, Shirogane, Takahiro, Xu, Lai, Nalepa, Grzegorz, Qin, Jun, Elledge, Stephen J., Harper, J. Wade
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cold Spring Harbor Laboratory Press 2003
Assuntos:	Research Papers
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305258/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14681206/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.1157503
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