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Phencyclidine is a negative allosteric modulator of signal transduction at two subclasses of excitatory amino acid receptors.

Phencyclidine (PCP) and some of its pharmacological congeners inhibit the signal transduction at specific excitatory amino acid receptors of cerebellar granule cells in primary cultures. These drugs do not bind to the transmitter recognition sites, and affinity of this specific binding site is incre...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Wroblewski, J T, Nicoletti, F, Fadda, E, Costa, E
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1987
Fag:
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC305248/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3037532/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.14.5068
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