Probiotic Sonicates Selectively Induce Mucosal Immune Cells Apoptosis through Ceramide Generation via Neutral Sphingomyelinase

BACKGROUND: Probiotics appear to be beneficial in inflammatory bowel disease, but their mechanism of action is incompletely understood. We investigated whether probiotic-derived sphingomyelinase mediates this beneficial effect. METHODOLOGY/PRINCIPAL FINDINGS: Neutral sphingomyelinase (NSMase) activi...

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Main Authors: Angulo, Sandra, Morales, Albert, Danese, Silvio, Llacuna, Laura, Masamunt, Maria Carme, Pultz, Nicole, Cifone, Maria Grazia, De Simone, Claudio, Delgado, Salvadora, Vila, Jordi, Panés, Julián, Donskey, Curtis, Fernández-Checa, Jose C., Fiocchi, Claudio, Sans, Miquel
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
נושאים:
Research Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052310/
https://ncbi.nlm.nih.gov/pubmed/21408067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0016953
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