Off-Target Function of the Sonic-Hedgehog Inhibitor Cyclopamine in Mediating Apoptosis via Nitric Oxide-Dependent Neutral Sphingomyelinase 2/Ceramide Induction

Sonic hedgehog (SHh) signaling is important in the pathogenesis of various human cancers, such as medulloblastomas, and it has been identified as a valid target for anti-cancer therapeutics. The SHh inhibitor cyclopamine induces apoptosis. The bioactive sphingolipid ceramide mediates cell death in r...

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Main Authors: Meyers-Needham, Marisa, Lewis, Jocelyn A., Gencer, Salih, Sentelle, R. David, Saddoughi, Sahar A., Clarke, Christopher J., Hannun, Yusuf A., Norell, Haakan, da Palma, Telma Martins, Nishimura, Michael, Kraveka, Jacqueline M., Khavandgar, Zohreh, Murshed, Monzur, Cevik, M. Ozgur, Ogretmen, Besim
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3709261/
https://ncbi.nlm.nih.gov/pubmed/22452947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-11-0705
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