Synergistic Protection in Lung Ischemia-Reperfusion Injury With Calcineurin and Thrombin Inhibition

BACKGROUND: Ischemia-reperfusion injury impairs lung transplant outcomes. The transcription factors, activator protein-1, and nuclear factor kappa B, are activated early in reperfusion and drive the development of injury. Thrombin inhibition with hirudin, and calcineurin inhibition with tacrolimus h...

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Autori principali: McCourtie, Anton S., Merry, Heather E., Wolf, Patrick S., FitzSullivan, Elizabeth, Keech, John C., Farivar, Alexander S., Mulligan, Michael S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3052279/
https://ncbi.nlm.nih.gov/pubmed/20494024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.athoracsur.2010.02.068
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